"radiotherapeutic management of early breast cancer after conservative surgery "

نویسندگان

"ghalibafian m

haddad p

dehshiri k "

چکیده

breast conservation surgery combined with radiation therapy is now an accepted option for the treatment of early breast cancer. so we decided to evaluate the results of such treatment in our first group of patients treated by this method. from 1992 to 1996 , one hundred patients with stage i and ii breast cancer treated with breast conservative surgery (lumpectomy or quadrantectomy). were irradated at tehran cancer institue and marie curie clinic. in stage ii the whole breast and the draining lymph-node areas, and in stage i only the breast were irradiated to 50 gray (gy) in 5 weeks using cobat 60. a bososter dose of 10 gy was given at the primary tumor site by photons in 1 weeks. thirty- eight percent of patients received adjuvant chemotherapy. tomoxifen was given to 96% . with a mean and median follow-up time of more than 3 years, three local recurrences and eight distant metastases occurred. the estimated 5 –year recurrence-free survival rate was 92% and the metastasis-free survival rate was 81%. seventy-seven percent were disease-free with preserved breast. young patient and those with positive margins had a higher risk for local failure. nodal metastasis and the omission of adjuvant tamoxifen increased the distant failure rate. complications were rare, excep for mild telangiectasia in four patients. the cosmetic result was exccllent or good in 90% of patients and the only factor with a statistically significant effect on cosmetic result was the treatment of both tangential fields per day.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Conservative Surgery for Early Breast Cancer

Wide local excision followed by radiotherapy was offered as an alternative to mastectomy to 93 women on 96 occasions. Complications attributable to the surgery occurred in 4 per cent whilst 37.5 per cent developed complications secondary to the radiotherapy. The complications were generally of a mild nature. Nine patients (9.3%) have developed regional recurrence and seventeen (17.7%) distant m...

متن کامل

Management of early breast cancer with breast conservative surgery. An egyptian experience.

BACKGROUND Breast conservative surgery (BCS) has been an established method for treatment of early breast cancer. The volume of the procedure varies from a wide local excision to partial mastectomy and ipsilateral axillary lymphadenectomy. The nipple and areola complex sparing, depends on their proximity to the tumour. Radiotherapy, chemotherapy and or hormonal treatment play an integral role i...

متن کامل

Concomitant Boost Radiotherapy after Conservative Breast Surgery in Early Breast Cancer

Background: Radiation therapy after breast conserving surgery is a standard part of treatment for invasive breast cancer. Based on radiobiological models, it was found that shorter radiation schedules offered the promise of equivalent local control to standard radiation therapy by giving larger doses per fraction in shorter period of time. Methods: This study included 36 female patients with op...

متن کامل

Conservative surgery and radiotherapy for early breast cancer.

In 1984, as part of a prior American Cancer Society National Conference on Breast Cancer, the authors reported on the status of conservative surgery (CS) and radiotherapy (RT) as primary local treatment for women with early stage breast cancer. Since that time, additional data have become available regarding the use of this approach and its comparability to mastectomy. In general, these data su...

متن کامل

[Resection margins in conservative breast cancer surgery].

Conservative breast cancer surgery is facing a new problem: the potential tumour involvement of resection margins. This eventuality has been closely and negatively associated with disease-free survival. Various factors may influence the likelihood of margins being affected, mostly related to the characteristics of the tumour, patient or surgical technique. In the last decade, many studies have ...

متن کامل

Depression and conservative surgery for breast cancer

BACKGROUND Depression is prevalent among women and associated with reduced quality of life, and therefore it is important to determine its incidence in adult women, especially in those with breast cancer. OBJECTIVE To determine the occurrence of depression in women who underwent conservative surgery for breast cancer with or without breast reconstruction. METHODS Seventy-five women aged bet...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
acta medica iranica

جلد ۳۸، شماره ۳، صفحات ۱۶۰-۱۶۵

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023